REFORCYL^®-AION contains free amino acids, polyphenols and carbohydrates from organic cultivated Cucurbita pepo var. styriaca seed press cake. The mixture of powerful ingredients is able to induce autophagy, supply the cells with optimal nutrition, rejuvenate and detox cells from within.

Ageing cells have a decreased turnover of cellular components and they tend to accumulate misfolded proteins and damaged organelles within cytoplasm. Garb’ageing is the consequence and skin deteriorates. It reminds one of the overfilled closet with the clothes we no longer wear but still keep. Only a regular clearing out can make room for new things. The mechanism of autophagy functions as a cellular clearing and recycling centre, ensuring the upcycling of unusable cell waste into new cellular building blocks. REFORCYL^®-AION rejuvenates and purifies the skin by activating the key parameters of autophagy, namely Golgi apparatus disassembly, mitochondrial fitness and LC3 gene upregulation.

Clinical studies have shown that activating this form of cellular spring-cleaning markedly improved skin tone and lead to smooth, redensified skin, providing holistic upcycled look to ageing skin. The improvement in the barrier effect, TEWL, hydration, firmness and elasticity of the skin was not only measureable but also tangible.

In-vitro studies revealed the disassembly of the Golgi apparatus, the most important organelle in autophagy process. Furthermore, the mitochondrial health was maintained and their fusion to an energy-rich network was promoted. LC3 gene that is responsible for the fusion with lysosome, the enzymatic waste degradation system was significantly upregulated.