CELLACTIVE^®-PDRN is a next generation active ingredient designed to address one of the fundamental mechanisms of skin ageing: the progressive decline of the skin’s natural repair capacity. By supporting recovery from daily stress, it helps strengthen resilience and promotes a healthier, more balanced and revitalised appearance. It is based on polydeoxyribonucleotides (PDRN), biologically active DNA fragments derived from microalgae and inspired by regenerative medicine.

Every day, the skin is challenged by environmental and lifestyle stressors such as UV exposure, pollution and oxidative stress. Over time, these factors can impair the skin’s ability to recover efficiently, leading to reduced resilience and visible signs of ageing and imbalance.

CELLACTIVE^®-PDRN supports the skin’s natural repair processes by interacting with cellular pathways involved in regeneration, helping the skin recover more effectively rather than only addressing surface-level symptoms.

Clinical studies show that CELLACTIVE^®-PDRN reinforces the skin’s structural network by supporting collagen and elastin production, essential for maintaining dermal strength and elasticity. As this matrix is strengthened, skin appears firmer and more resilient, with visible improvements in wrinkles and hydration, alongside reduced redness and increased barrier function. In-vitro data further confirm an increase in collagen I and III and elastin production, A_2A receptor activation and modulation of inflammatory responses, supporting the underlying regenerative mechanisms.

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